It can spoil you, rotten.  I keep about ten guitars out a rack and on stands, that I use in rotation, because I like the variety of sounds and feel of different guitars. Well, I hadn't played any of my other guitars in the last month, since I got the Hallmark 60 Custom. When I first got it I had to get accustomed to the smaller frets and thinner neck. It didn't take long and I really enjoy playing it, now. 
Last night I decided I had better start playing my other guitars. WOW!!! I first picked up an "Agile" Strat copy (very nice guitar BTW). The neck felt like a fence post and the frets were like railroad ties. 

 I could hardly play the thing. I felt hindered and slow. But, what really shocked me, was how huge the dot fret markers looked. 
 So I put it down and picked up my 335. It was easier to get acclimated too, but still felt slow and clumsy. 
Has anyone else experienced this adjustment when going from a "Mosrite" type neck to a run-of-the-mill guitar neck?